Atherogenic diet alters folate enzymes in mice: implications of folate deficient homocysteinemia.
Indian J Biochem Biophys
;
1998 Oct; 35(5): 303-7
Article
in English
| IMSEAR
| ID: sea-27350
ABSTRACT
The two key enzymes, methylenetetrahydrofolate reductase and methionine synthase involved in methionine synthesis from homocysteine were studied in atherogenic diet fed mice. Methylenetetrahydrofolate reductase activity was elevated while methionine synthase was impaired in atherogenic diet fed group. Impaired methionine synthase activity would adversely affect the methionine synthesis from homocysteine, resulting in a rise in the homocysteine levels, which are atherogenic. This is reflected by the increased levels of very low density and low density lipoprotein cholesterol values and a higher ratio for total cholesterol to high density lipoprotein cholesterol.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase
/
Male
/
Methylenetetrahydrofolate Reductase (NADPH2)
/
Diet, Atherogenic
/
Folic Acid Deficiency
/
Oxidoreductases Acting on CH-NH Group Donors
/
Homocysteine
/
Animals
/
Mice
/
Mice, Inbred C57BL
Language:
English
Journal:
Indian J Biochem Biophys
Year:
1998
Type:
Article
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