Effect of anticalmodulin and antitubulin on LDL-receptor synthesis in aortic smooth muscle cells cultured in vitro.
Indian J Biochem Biophys
;
1990 Aug; 27(4): 251-3
Article
in English
| IMSEAR
| ID: sea-27445
ABSTRACT
Effect of trifluoperazine and colchicine on LDL-receptor synthesis in smooth muscle cells exposed to hypercholesterolemic medium in vitro have been studied. While trifluoperazine at 25 microM concentration caused stimulation of LDL-receptor synthesis, colchicine acted as a dose-dependent inhibitor of LDL-receptor synthesis. Thus calmodulin down regulates LDL-receptor synthesis independent of microtubular involvement.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Trifluoperazine
/
Calmodulin
/
Receptors, LDL
/
Cells, Cultured
/
Colchicine
/
Tubulin Modulators
/
Animals
/
Muscle, Smooth, Vascular
Language:
English
Journal:
Indian J Biochem Biophys
Year:
1990
Type:
Article
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