Effect of perchlorate on mitochondrial function.
Indian J Biochem Biophys
;
1990 Feb; 27(1): 48-51
Article
in English
| IMSEAR
| ID: sea-27583
ABSTRACT
Administration of sodium perchlorate to rats for 45 days leads to decreased activities of citric acid cycle enzymes. The oxidation of succinate both in state 3 and state 4 conditions and endogenous ATP content of mitochondria decreased during perchlorate toxicity. The significant decrease in cytochrome aa3 in perchlorate-treated rats may be one of the prime factors involved in the decreased rate of respiration. The permeability of mitochondria of perchlorate-treated rats is altered as indicated by increased oxidation of NADH and low respiratory control ratio (RCR).
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Rats
/
Rats, Inbred Strains
/
Male
/
Mitochondria, Liver
/
Perchlorates
/
Kidney
/
Animals
/
Mitochondria
Language:
English
Journal:
Indian J Biochem Biophys
Year:
1990
Type:
Article
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