Wobble base-pairing in codon-anticodon interactions: a theoretical modelling study.
Indian J Biochem Biophys
;
2001 Feb-Apr; 38(1-2): 115-9
Article
in English
| IMSEAR
| ID: sea-27945
ABSTRACT
The Crick wobble hypothesis attributes the phenomenon of codon degeneracy to a certain impreciseness of pairing between the third base of the codon and the first base of the anticodon. This theoretical study investigates the pairing properties of some wobble bases, including both, observed and unobserved pairs. Some wobble base-pairs are predicted to follow the Watson-Crick pairs in configuration and pairing facility, while others deviate from this norm. The observed UV pair is unique in that a pairing configuration may be suggested for it wherein the hydrogen-bonding involves the exocyclic 5-carboxymethoxy group of V. By comparing the theoretical data on the configurations of these pairs with the evidence for their existence/non-existence in nature, some guidelines emerge for differentiating between observed and unobserved base pairs on the basis of the pairing configuration.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Uracil
/
Computer Simulation
/
Anticodon
/
Codon
/
DNA
/
Adenine
/
Base Pairing
/
Cytosine
/
Guanine
/
Hydrogen Bonding
Type of study:
Prognostic study
Language:
English
Journal:
Indian J Biochem Biophys
Year:
2001
Type:
Article
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