Relationship of single-stranded DNA-binding proteins of Ehrlich ascites tumour to cell growth phase and DNA replications.
Indian J Biochem Biophys
;
1992 Feb; 29(1): 9-12
Article
in English
| IMSEAR
| ID: sea-27947
ABSTRACT
The possible involvement of SSB-proteins in DNA replication in Ehrlich ascites tumour (EAT) has been investigated. A direct relation (the computer-generated correlation coefficient was 0.9) between the SSB-proteins content in chromatin and intensity of the replicative synthesis of DNA in various preparation of EAT in vivo and in vitro is observed. Addition of exogenous SSB-proteins to the permeable EAT cells has been found to increase the replicative synthesis. Although eukaryotic SSB-proteins are not complete analogs of the prokaryotic SSB-proteins, they evidently participate in DNA replication in eukaryotic cells and possibly are intracellular regulators of proliferation.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Male
/
DNA, Single-Stranded
/
Carcinoma, Ehrlich Tumor
/
Cell Division
/
DNA-Binding Proteins
/
DNA Replication
/
Animals
/
Mice
/
Neoplasm Proteins
Language:
English
Journal:
Indian J Biochem Biophys
Year:
1992
Type:
Article
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