Quantitative structure activity relationship (QSAR) studies of some substituted benzenesulphonyl glutamines as tumour suppressors.
Indian J Biochem Biophys
;
2001 Feb-Apr; 38(1-2): 120-3
Article
in English
| IMSEAR
| ID: sea-27987
ABSTRACT
As a part of a composite programme of rational drug design (RDD), we had synthesized some substituted benzenesulphonyl glutamines and evaluated their inhibitory activities against Ehrlich Ascites Carcinoma (EAC) cell line in Swiss albino mice. Quantitative structure activity relationship (QSAR) studies of these inhibitory activities using Fujita-Ban model as well as Modified Hansch-Fujita model gave excellent correlations (correlation coefficient r = 0.89 and 0.82 respectively). These results could be useful in designing 'lead' compound with potent inhibitory activity on DNA and RNA synthesis and tumour development.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Structure-Activity Relationship
/
Benzenesulfonates
/
DNA
/
RNA
/
Tumor Cells, Cultured
/
Glutamine
/
Animals
/
Mice
/
Models, Chemical
/
Models, Theoretical
Language:
English
Journal:
Indian J Biochem Biophys
Year:
2001
Type:
Article
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