Targeting of piperine intercalated in mannose-coated liposomes in experimental leishmaniasis.
Indian J Biochem Biophys
;
1999 Aug; 36(4): 248-51
Article
in English
| IMSEAR
| ID: sea-28085
ABSTRACT
The leishmanicidal property of piperine intercalated in liposomes and in mannose-coated liposomes was tested in experimental visceral leishmaniasis in hamsters. Mannose-coated liposomal piperine eliminated intracellular amastigotes of Leishmania donovani in splenic macrophages much more efficiently than did the liposomal piperine or free piperine. At a dose equivalent to 6 mg/kg body wt every 4th day for a total of 4 doses in 12 days, the mannose-coated liposomal piperine was found to reduce spleen parasite load to the extent of 90% in comparison to that achieved by liposomal piperine (77%) or free piperine (29%). Histological examination of spleen and liver function tests showed that the toxicity of piperine was reduced when mannosylated liposomal piperine was administered.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Piperidines
/
Spleen
/
Drug Carriers
/
Cricetinae
/
Mesocricetus
/
Alkaloids
/
Benzodioxoles
/
Polyunsaturated Alkamides
/
Leishmaniasis, Visceral
/
Liposomes
Language:
English
Journal:
Indian J Biochem Biophys
Year:
1999
Type:
Article
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