Deranged folic acid metabolism in diabetes-induced rats.
Indian J Biochem Biophys
;
1994 Feb; 31(1): 68-72
Article
in English
| IMSEAR
| ID: sea-28154
ABSTRACT
Metabolic changes in the folic acid and their conjugated polyglutamyl derivatives have been studied in streptozotocin-induced diabetic rats. Conjugated folates which constituted about 70% in normal rat liver get rapidly hydrolysed to simple unconjugated forms as the diabetes progressed leaving behind only 2% after 25 days of the onset of diabetes. Chromatographic analysis shows significant alterations in the formyl- and methyltetrahydrofolate derivatives and their polyglutamylation profiles. A 7-8 fold higher urinary excretion of mainly methyltetrahydrofolate is also observed in diabetic rats.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Rats
/
Male
/
Rats, Wistar
/
Diabetes Mellitus, Experimental
/
Folic Acid
/
Animals
Language:
English
Journal:
Indian J Biochem Biophys
Year:
1994
Type:
Article
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