Influence of 7beta-hydroxycholesterol on glutathione status and nitric oxide production in macrophages: in vitro studies.
Indian J Biochem Biophys
;
2001 Jun; 38(3): 176-9
Article
in English
| IMSEAR
| ID: sea-28189
ABSTRACT
Incubation of murine peritoneal macrophages with 7beta-hydroxycholesterol (7beta-OH) for 24 hr led to dose-dependent reduction in cellular glutathione content as well as nitrite levels in the medium. Treatment with an inorganic form of selenium, sodium selenite which is a potent antioxidant, elevated the cellular glutathione levels and decreased nitrite levels. Our results suggest that 7beta-OH may exert its pro-atherogenic effect by inhibiting glutathione synthesis and nitric oxide production by macrophages present in the arterial wall and thus, impair the cellular antioxidant defense system.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Arteries
/
Selenium
/
Time Factors
/
Cells, Cultured
/
Macrophages, Peritoneal
/
Dose-Response Relationship, Drug
/
Glutathione
/
Glutathione Peroxidase
/
Hydroxycholesterols
/
Animals
Language:
English
Journal:
Indian J Biochem Biophys
Year:
2001
Type:
Article
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