Effect of alpha-tocopherol on mitochondrial electron transport in experimental myocardial infarction in rats.
Indian J Biochem Biophys
;
1998 Apr; 35(2): 115-9
Article
in English
| IMSEAR
| ID: sea-28477
ABSTRACT
The effect of alpha-tocopherol pretreatment (6 mg/100 g body wt/day, orally for a period of 90 days) on mitochondrial electron transport in myocardial infarction induced by isoproterenol (20 mg/100 g body wt, subcutaneously for two days) was studied in rats. A significant decrease was observed in the activities of isocitrate dehydrogenase, alpha-ketoglutarate dehydrogenase, succinate dehydrogenase, malate dehydrogenase, NADH dehydrogenase and cytochrome oxidase in heart mitochondria of isoproterenol administered rats. The cytochrome content and the oxidation of succinate in state 3 and state 4 decreased significantly in the cardiac mitochondria treatment. In alpha-tocopherol pretreated rats, the activities of TCA cycle enzymes, concentration of cytochromes and the oxidation of succinate in state 3 and state 4 were retained at near normal values, following isoproterenol administration.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Rats
/
Reference Values
/
Vitamin E
/
Male
/
Lipid Peroxidation
/
Citric Acid Cycle
/
Rats, Wistar
/
Cytochromes
/
Electron Transport
/
Isoproterenol
Language:
English
Journal:
Indian J Biochem Biophys
Year:
1998
Type:
Article
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