Importance of glycoproteins in human cancer.
Indian J Biochem Biophys
;
1997 Feb-Apr; 34(1-2): 226-33
Article
in English
| IMSEAR
| ID: sea-28539
ABSTRACT
Usefulness of cell surface glycoprotein components as markers in early detection of cancer and in monitoring progress during treatment has been evaluated. Total sialic acid (TSA), lipid bound sialic acid (LSA) and seromucoid fractions (SF) have been compared in the sera of healthy human volunteers and patients at different stages of diagnosis and treatment of leukemia, cancer of breast, cervix, and oral cavity. The levels of TSA, LSA and SF are found to be increased in cancer and is proportionate with malignancy. Their levels show decline in patients who respond well to treatment and show increase in patients with recurrence of cancer even before any clinical evidence of recurrence is available. Changes have also been noted in the glycoprotein fractions and their ratios.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Sialic Acids
/
Female
/
Humans
/
Male
/
Orosomucoid
/
Glycoproteins
/
Biomarkers, Tumor
/
Case-Control Studies
/
Neoplasm Proteins
/
Neoplasms
Type of study:
Observational study
/
Screening study
Language:
English
Journal:
Indian J Biochem Biophys
Year:
1997
Type:
Article
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