Functional proteomics of receptor-Ck in the developmental stages of human atherosclerotic arterial wall.
Indian Heart J
;
2003 May-Jun; 55(3): 252-5
Article
in English
| IMSEAR
| ID: sea-2859
ABSTRACT
BACKGROUND:
The study was undertaken to understand the relationship between the functional proteomics of receptor-Ck and developmental stages of human atherosclerotic aortic wall. METHODS ANDRESULTS:
Gene expression study of 25 aortas was undertaken and the results revealed a gradual increase in receptor-Ck gene expression paralleled by the regulatory response of its effector genes coding for sterol response element-binding protein, p27, cyclin D, interleukin-6 and CD40 from a normal to atherosclerotic arterial wall (viz. fatty streak and fibrofatty/fibrous plaque).CONCLUSIONS:
Based upon this and our earlier studies, we propose that cholesterol-specific receptor-Ck-dependent gene regulation may be of crucial importance in atherogenesis.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Aorta
/
Transcription Factors
/
Coronary Artery Disease
/
Humans
/
Carrier Proteins
/
Interleukin-6
/
Cyclins
/
Receptors, Lipoprotein
/
Gene Expression Regulation, Developmental
/
CCAAT-Enhancer-Binding Proteins
Country/Region as subject:
Asia
Language:
English
Journal:
Indian heart j
Year:
2003
Type:
Article
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