Induction of apoptosis in AK-5 cells by rotenone involves participation of caspases.
Indian J Biochem Biophys
;
1999 Apr; 36(2): 77-81
Article
in English
| IMSEAR
| ID: sea-28640
ABSTRACT
AK-5 tumour cells undergo apoptosis after treatment with rotenone an electron transport inhibitor and oligomycin which inhibits mitochondrial ATPases. Apoptotic process involves the induction of caspases 2 and 3, whereas caspase 1 does not seem to be participating in rotenone/oligomycin induced apoptosis. DEVD which is a specific inhibitor of caspase 3, inhibited apoptosis in AK-5 cells. We have also observed a significant lowering of intracellular pH in AK-5 cells which are induced into the apoptotic process by rotenone. These results suggest an important role for mitochondrial electron transport in the induction of apoptosis in AK-5 tumour cells.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Rats
/
Rotenone
/
Tumor Cells, Cultured
/
Rats, Wistar
/
Apoptosis
/
Caspases
/
Animals
Language:
English
Journal:
Indian J Biochem Biophys
Year:
1999
Type:
Article
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