Conformational transitions and specific heat anomaly in poly(dG-dC) and its methylated analogue.
Indian J Biochem Biophys
;
1992 Dec; 29(6): 449-57
Article
in English
| IMSEAR
| ID: sea-28658
ABSTRACT
The Zimm and Bragg theory of the helix<-->coil transition has been modified to explain order<-->order transitions in polynucleotides, in particular B<-->Z<-->psi(-)<-->coil transitions in poly(dG-dC) and poly(dG-me5dC). Lambda anomalies in specific heat measurements around the transition point have also been explained by a further modification of the same theory. Theoretical results are found to be in good agreement with the experimental data. The nucleation parameter is consistent with the stabilization/destabilization of the ordered states (Z helix) under various environmental conditions, e.g. methylation of cytosine residue at C5 position or change in the cationic concentration of the solvent.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Polydeoxyribonucleotides
/
Thermodynamics
/
Calorimetry
/
Kinetics
/
Hot Temperature
/
Mathematics
/
Nucleic Acid Conformation
Language:
English
Journal:
Indian J Biochem Biophys
Year:
1992
Type:
Article
Similar
MEDLINE
...
LILACS
LIS