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Metabolism of 5-aminoquinoline with liver cytosol enzyme.
Indian J Biochem Biophys ; 1993 Aug; 30(4): 229-33
Article in English | IMSEAR | ID: sea-28724
ABSTRACT
In vitro oxidation and acetylation of 5-aminoquinoline by rabbit liver enzyme preparation has been investigated. Incubation of 5-aminoquinoline with cytosol fraction of the enzyme preparation in the presence of acetyl coenzyme-A gave rise to three different products, viz. 5-amino-2-hydroxy quinoline, 5-acetyl-aminoquinoline and 5-acetylamino-2-hydroxy quinoline due to the combined action of aldehyde oxidase and N-acetyl transferase. The metabolites thus obtained by enzyme catalysed reactions were isolated and separated by TLC, HPLC and subsequently characterised by IR and mass spectral fragmentation techniques.
Subject(s)
Full text: Available Index: IMSEAR (South-East Asia) Main subject: Oxidation-Reduction / Acetylation / Rabbits / Acetyltransferases / Mass Spectrometry / Female / Kinetics / Biotransformation / Chromatography, High Pressure Liquid / Chromatography, Thin Layer Language: English Journal: Indian J Biochem Biophys Year: 1993 Type: Article

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Full text: Available Index: IMSEAR (South-East Asia) Main subject: Oxidation-Reduction / Acetylation / Rabbits / Acetyltransferases / Mass Spectrometry / Female / Kinetics / Biotransformation / Chromatography, High Pressure Liquid / Chromatography, Thin Layer Language: English Journal: Indian J Biochem Biophys Year: 1993 Type: Article