Metabolism of 5-aminoquinoline with liver cytosol enzyme.
Indian J Biochem Biophys
;
1993 Aug; 30(4): 229-33
Article
in English
| IMSEAR
| ID: sea-28724
ABSTRACT
In vitro oxidation and acetylation of 5-aminoquinoline by rabbit liver enzyme preparation has been investigated. Incubation of 5-aminoquinoline with cytosol fraction of the enzyme preparation in the presence of acetyl coenzyme-A gave rise to three different products, viz. 5-amino-2-hydroxy quinoline, 5-acetyl-aminoquinoline and 5-acetylamino-2-hydroxy quinoline due to the combined action of aldehyde oxidase and N-acetyl transferase. The metabolites thus obtained by enzyme catalysed reactions were isolated and separated by TLC, HPLC and subsequently characterised by IR and mass spectral fragmentation techniques.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Oxidation-Reduction
/
Acetylation
/
Rabbits
/
Acetyltransferases
/
Mass Spectrometry
/
Female
/
Kinetics
/
Biotransformation
/
Chromatography, High Pressure Liquid
/
Chromatography, Thin Layer
Language:
English
Journal:
Indian J Biochem Biophys
Year:
1993
Type:
Article
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