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Amsacrine binds in a cooperative manner to deoxyribonucleic acid.
Indian J Biochem Biophys ; 1990 Aug; 27(4): 219-21
Article in English | IMSEAR | ID: sea-28732
ABSTRACT
The intercalative binding of the acridine antitumour drug 4'-(9-acridinylamino) methane-sulphonate-m-anisidine, a known inhibitor of nucleic acid synthesis, to native calf thymus DNA has been studied using optical titration method. Amsacrine (AMSA) exhibits positive cooperativity in their equilibrium binding to DNA as indicated by the positive slope in the initial region of the binding isotherms (Scatchard plots) under conditions simulating physiological ionic strengths. m-AMSA binds with a higher degree of cooperativity than o-AMSA. Although this correlates with the effectiveness of the drugs as antitumour agents, the exact relationship between the observation of cooperative binding and pharmacological activity is yet to be determined.
Subject(s)
Full text: Available Index: IMSEAR (South-East Asia) Main subject: Binding Sites / Biophysics / Amsacrine / DNA / Cattle / Kinetics / Biophysical Phenomena / Animals Language: English Journal: Indian J Biochem Biophys Year: 1990 Type: Article

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Full text: Available Index: IMSEAR (South-East Asia) Main subject: Binding Sites / Biophysics / Amsacrine / DNA / Cattle / Kinetics / Biophysical Phenomena / Animals Language: English Journal: Indian J Biochem Biophys Year: 1990 Type: Article