Gramicidin channels--a solvable membrane "protein" folding problem.
Indian J Biochem Biophys
;
1996 Oct; 33(5): 331-42
Article
in English
| IMSEAR
| ID: sea-28736
ABSTRACT
The linear gramicidins are peptide antibiotics that form cation-selective channels in lipid bilayers. Gramicidin channels have very well-defined functional characteristics, and the structure of membrane-spanning gramicidin A channels is known at atomic resolution. These features make the gramicidins well suited to study how the amino acid sequence encodes the structure and function of a membrane-spanning channel. We show how one can use electrophysiological measurements to obtain structural information about conducting channels and to quantify the conformational preferences of sequence-substituted gramicidin mutants.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Protein Conformation
/
Molecular Sequence Data
/
Models, Molecular
/
Amino Acid Sequence
/
Protein Folding
/
Gramicidin
/
Ion Channels
/
Lipid Bilayers
/
Membrane Proteins
Type of study:
Prognostic study
Language:
English
Journal:
Indian J Biochem Biophys
Year:
1996
Type:
Article
Similar
MEDLINE
...
LILACS
LIS