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Induction of oxidative stress by restraint stress and corticosterone treatments in rats.
Indian J Biochem Biophys ; 2009 Feb; 46(1): 53-8
Article in English | IMSEAR | ID: sea-28834
ABSTRACT
Chronic exposure to psychological stress in humans and restraint stress in experimental animals results in increased oxidative stress and resultant tissue damage. To study the contribution of stress hormones towards stress-induced oxidative processes in the brain, we investigated the response of important free-radical scavenging enzymes toward chronic administration of two doses of corticosterone (low dose 10 mg/kg/day, high dose 40 mg/kg/day) in rodents. After a 21-day experimental period, a significant decline in both superoxide dismutase and catalase was observed in both stressed and stress hormone-treated animals. The brain levels of glutathione as well as the activities of glutathione-S-transferase and glutathione reductase were also significantly decreased, while lipid peroxidation levels were significantly increased in comparison to controls. A direct pro-oxidant effect of stress hormones in the brain during physical and psychological stress was observed, indicating important implications for oxidative stress as a major pathological mechanism during chronic stress and a consequent target option for anti-stress therapeutic interventions.
Subject(s)
Full text: Available Index: IMSEAR (South-East Asia) Main subject: Rats / Stress, Psychological / Superoxide Dismutase / Blood Glucose / Brain / Restraint, Physical / Corticosterone / Lipid Peroxidation / Catalase / Random Allocation Language: English Journal: Indian J Biochem Biophys Year: 2009 Type: Article

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Full text: Available Index: IMSEAR (South-East Asia) Main subject: Rats / Stress, Psychological / Superoxide Dismutase / Blood Glucose / Brain / Restraint, Physical / Corticosterone / Lipid Peroxidation / Catalase / Random Allocation Language: English Journal: Indian J Biochem Biophys Year: 2009 Type: Article