200 picosecond molecular dynamics simulation of interaction of nifedipine with 1-2 dimyristoyl phosphatidylcholine membrane.
Indian J Biochem Biophys
;
1994 Feb; 31(1): 24-30
Article
in English
| IMSEAR
| ID: sea-28869
ABSTRACT
Interaction of calcium channel antagonist nifedipine (Nif) with 1-2 dimyristoyl phosphatidylcholine (DMPC) membrane has been studied using molecular dynamics approach. The simulations for one molecule of nifedipine with four DMPC molecules were carried out for 200 pico seconds (ps) using AMBER (Assisted Model Building with Energy Refinement) 3.0 adopted to CYBER 180/930 computer and changes in the structural parameters of DMPC were compared with those for DMPC monolayer (a matrix of nine molecules) optimized separately. Dynamics simulations for the latter had been carried for 40 ps. Our results show that the drug molecule (Nif) penetrates a discrete depth within the phospholipid matrix causing hydrocarbon chains of lipid molecules to swing that makes enough room for the receptor adjacent to the drug molecule.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Time Factors
/
Computer Simulation
/
Nifedipine
/
Models, Molecular
/
Dimyristoylphosphatidylcholine
/
Membranes, Artificial
Type of study:
Prognostic study
Language:
English
Journal:
Indian J Biochem Biophys
Year:
1994
Type:
Article
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