Functional and biosynthetic aspects of sialic acid diversity.
Indian J Biochem Biophys
;
1997 Feb-Apr; 34(1-2): 131-41
Article
in English
| IMSEAR
| ID: sea-28926
ABSTRACT
Sialic acids comprise a large family of N- and O-substituted neuraminic acid derivatives as components of glycoconjugates. N-Glycolylneuraminic acid is formed from N-acetylneuraminic acid by the action of the CMP-N-acetylneuraminic acid hydroxylase studied in various animals. O-Methylated sialic acids originate from the action of S-adenosylmethionine-8-O-methyltransferase studied in starfish. Sialic acids are O-acetylated at diverse positions by the action of acetyl-CoA-4-O- and -7-O-acetyltransferases found in various animals and, leading to the O-acetylation of sialic acid glycerol side chain, also in man. Some properties of these enzymes are described and biological implications discussed.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Acetyl-CoA C-Acetyltransferase
/
Acetylation
/
Sialic Acids
/
Starfish
/
Humans
/
Molecular Structure
/
Mixed Function Oxygenases
/
Animals
/
Methylation
/
Methyltransferases
Language:
English
Journal:
Indian J Biochem Biophys
Year:
1997
Type:
Article
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