Effect of nitrous oxide and methionine on hepatic S-adenosylmethionine levels and in vivo histidine oxidation in rats.
Indian J Biochem Biophys
;
1992 Oct; 29(5): 415-7
Article
in English
| IMSEAR
| ID: sea-28953
ABSTRACT
Nitrous oxide (N2O) decreased in vivo oxidation of histidine in rats fed a basal diet marginally deficient in methionine, although hepatic levels of S-adenosylmethionine (AdoMet) were not significantly altered. Excess dietary methionine increased hepatic levels of AdoMet and increased histidine oxidation. However, it did not protect histidine oxidation when the rats were treated with N2O. Parenteral administration of methionine greatly increased hepatic levels of AdoMet and increased histidine oxidation in normal and N2O treated rats. This indicates that when hepatic levels of AdoMet are greatly elevated by administration of methionine, N2O does not affect in vivo histidine oxidation.
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Index:
IMSEAR (South-East Asia)
Main subject:
Rats
/
S-Adenosylmethionine
/
Male
/
Kinetics
/
Rats, Sprague-Dawley
/
Histidine
/
Liver
/
Animals
/
Methionine
/
Nitrous Oxide
Language:
English
Journal:
Indian J Biochem Biophys
Year:
1992
Type:
Article
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