Differential effects of chronic endosulfan exposure to male rats in relation to hepatic drug metabolism and androgen biotransformation.
Indian J Biochem Biophys
;
1989 Aug; 26(4): 262-7
Article
in English
| IMSEAR
| ID: sea-29070
ABSTRACT
Chronic endosulfan exposure in rats led to considerable increase in the activities of drug metabolizing enzymes, whereas it had inhibitory effect on the activities of enzymes involved in the androgen biotransformation. Endosulfan also produced a dose- and duration-dependent increase in microsomal lipid peroxidation. The alterations produced after shorter duration showed much variation with respect to the dose levels and exposure period of endosulfan studied. The above biochemical changes were reversed after endosulfan withdrawal.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Rats
/
Rats, Inbred Strains
/
Male
/
Microsomes, Liver
/
Inactivation, Metabolic
/
Endosulfan
/
Androgens
/
Liver
/
Animals
Language:
English
Journal:
Indian J Biochem Biophys
Year:
1989
Type:
Article
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