Role of corticosteroids in the management of chronic obstructive lung disease: factors predicting response.
Indian J Chest Dis Allied Sci
;
1992 Jan-Mar; 34(1): 11-7
Article
in English
| IMSEAR
| ID: sea-29509
ABSTRACT
A double-blind crossover trial of prednisolone was conducted in 70 patients of chronic obstructive lung disease (COLD). Emphysema dominated the clinical picture in 38, rest being chronic bronchitis with varying degrees of air trapping. None of the patients had clinical asthma. All the patients had obtained maximal benefit from an optimal dose of bronchodilators prior to entering the study. Prednisolone in a dose of 0.8 mg/kg was prescribed in a double blind crossover manner with identical appearing placebo tablets. Patients were evaluated on a weekly basis for an objective as well as a subjective response and side effects of therapy. Thirty-four patients demonstrated a statistically significant improvement in pulmonary functions. In 20 others only subjective response was observed. A good objective response was predicted by a pre-study variability in FEV1, disease duration of less than 10 years and a history of smoking less than 50 pack years.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Pulmonary Emphysema
/
Respiratory Function Tests
/
Time Factors
/
Bronchitis
/
Female
/
Humans
/
Male
/
Prednisolone
/
Smoking
/
Forced Expiratory Volume
Type of study:
Controlled clinical trial
/
Prognostic study
Language:
English
Journal:
Indian J Chest Dis Allied Sci
Year:
1992
Type:
Article
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