A prospective study of sensitivity and specificity of adenosine deaminase estimation in the diagnosis of tuberculosis pleural effusion.
Indian J Chest Dis Allied Sci
;
2001 Jul-Sep; 43(3): 149-55
Article
in English
| IMSEAR
| ID: sea-30230
ABSTRACT
We prospectively evaluated the usefulness of adenosine deaminase [ADA] estimation in the diagnosis of tuberculosis [TB] pleural effusion. Seventy five subjects with pleural effusion were studied. Forty eight of them had TB pleural effusion [MF 3711; mean age 33 +/- 14.4 years range 17-76] and the remaining 27 had pleural effusion due to causes other than TB [non-TB group] [MF 198; mean age 47.3 +/- 16.5 years; range 17-75]. Pleural fluid [PF] ADA levels were significantly higher in TB (n=48; mean 95.8 +/- 57.5 IU/L) compared with non-TB group (n=27; mean 30.7 +/- 27.2 IU/L) [p<0.001]. Serum ADA [S-ADA] levels were also significantly higher in TB (n=45; mean 39.6 +/- 18.3 IU/L) compared with non-TB group (n=26; mean 18.0 +/- 13.7 IU/L) [p<0.001]. PF-ADA levels were higher compared to S-SDA in TB (p <0.001) and non-TB groups [p<0.01]. Using a cut off of 35 IU/L, the sensitivity and specificity of PF-ADA in the diagnosis of TB was computed to be 83.3% and 66.6% respectively. At a cut-off level of 100 IU/L, PF-ADA was found to have a sensitivity 40% and specificity 100%. From this study it is concluded that, using 100 IU/L as the cut-off, it is possible to avoid pleural biopsy to ascertain the diagnosis of TB in as much as 40% of the patients.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Pleural Effusion
/
Tuberculosis, Pleural
/
Aged
/
Female
/
Humans
/
Male
/
Adenosine Deaminase
/
Prospective Studies
/
Analysis of Variance
/
Sensitivity and Specificity
Type of study:
Diagnostic study
/
Observational study
Country/Region as subject:
Asia
Language:
English
Journal:
Indian J Chest Dis Allied Sci
Year:
2001
Type:
Article
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