Hypotension is a predictor of mortality in acute exacerbations of chronic obstructive pulmonary disease.
Indian J Chest Dis Allied Sci
;
2007 Jan-Mar; 49(1): 13-8
Article
in English
| IMSEAR
| ID: sea-30262
ABSTRACT
OBJECTIVES:
To identify variables that predict the in-hospital course and prognosis of patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD).METHODS:
A retrospective analysis of 94 patients (20 females) with AECOPD. Twenty-one variables including arterial blood gas studies were analysed.RESULTS:
The mean age was 61.2 years. The in-hospital mortality rate was 12.8%; 28.6% of patients required invasive mechanical ventilation and 37.2% required ICU care. In univariate analysis, aypotension at presentation (systolic blood-pressure < 90 mmHg) [p = 0.002, odds ratio OR 10.95, 95% confidence interval (CI) 1.90-63.00); central cyanosis (p = 0.007, OR 6.91, 95% CI 1.42-33.59); and cor-pulmonale (p = 0.009, OR 10.46, 95% CI 1.26-86.46) were univariately associated with in-hospital mortality. On multivariate analysis, hypotension (p = 0.049, OR 18.419, 95% CI 1.013-334.752) remained the only independent predictor.CONCLUSIONS:
More than the markers of poor gas exchange, the presence of hypotension indicates a poor in-hospital prognosis in AECOPD.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Respiration, Artificial
/
Aged
/
Female
/
Humans
/
Male
/
Retrospective Studies
/
Treatment Outcome
/
Hospital Mortality
/
Critical Care
/
Pulmonary Disease, Chronic Obstructive
Type of study:
Observational study
/
Prognostic study
/
Risk factors
Country/Region as subject:
Asia
Language:
English
Journal:
Indian J Chest Dis Allied Sci
Year:
2007
Type:
Article
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