Impact of vascular abnormalities in neoplastic and non-neoplastic lung disease.
Indian J Chest Dis Allied Sci
;
2005 Apr-Jun; 47(2): 103-7
Article
in English
| IMSEAR
| ID: sea-30498
ABSTRACT
BACKGROUND:
Vascular abnormalities of the pulmonary circulation in the setting of destructive lung diseases caused by inflammation or neoplasia has been scantily researched. A need was felt to document the spectrum of pathological alterations in the vasculature and thus permit speculation into both their pathogenesis and possible clinical significance.METHODS:
Between January 1999 and June 2001, 21 patients (malefemale 34) who had chest disease exceeding a duration of six months and later underwent lobectomy were included in the study. The histopathological material was analysed for vascular changes such as arterial intimal fibrosis, muscularisation of intima and pericapillary fibrosis. The study included a detailed morphometric analysis.RESULTS:
The lesions included 15 non-neoplastic diseases and six neoplastic diseases. The striking vasculopathic changes observed in the absence of pulmonary hypertension were pulmonary artery medial hypertropy (100%), intimal fibrosis (62%) and muscularisation of the neo-intima (3%). Pericapillary fibrosis was seen in 83% of the neoplastic lesions and 67% of the non-neoplastic lesions.CONCLUSION:
This study highlights the impact of chronic lung disease on pulmonary vasculature. The role that neoplastic and non-neoplastic lung disease have to play in the evolution of the documented vascular changes have been postulated, and the need to design effective therapeutic strategies to modulate hypoxia, reverse the inflammatory process and stabilise the fibroblastic process is also highlighted.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Prognosis
/
Reference Values
/
Respiratory Function Tests
/
Vascular Diseases
/
Female
/
Humans
/
Male
/
Endothelium, Vascular
/
Case-Control Studies
/
Child
Type of study:
Etiology study
/
Incidence study
/
Observational study
/
Prognostic study
/
Risk factors
Country/Region as subject:
Asia
Language:
English
Journal:
Indian J Chest Dis Allied Sci
Year:
2005
Type:
Article
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