Towards a malaria vaccine: riding the rollercoaster between unrealistic optimism and lethal pessimism.
Southeast Asian J Trop Med Public Health
;
1992 Dec; 23(4): 656-71
Article
in English
| IMSEAR
| ID: sea-30823
ABSTRACT
Activity in many laboratories over the past decade has resulted in many vaccine candidates nearing clinical trials. These include several antigens from the sporozoite stage; merozoite surface antigens MSA1 and MSA2, RESA, the rhoptry proteins RAP-1 and RAP-2 from the asexual blood stage; the pfs25, pfg45 and pfg230 from the ookinete and gamete stages. This progress in the identification of potential vaccine candidates now highlights a series of scientific, developmental, economic and operational problems the solutions to which will be as critical to the development of a vaccine as the cloning and expression of parasite genes.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Plasmodium
/
Humans
/
Protozoan Vaccines
/
Animals
/
Malaria
Language:
English
Journal:
Southeast Asian J Trop Med Public Health
Year:
1992
Type:
Article
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