Temporary appearance of a circulating granulocyte-macrophage colony-stimulating factor in lethal murine malaria.
Southeast Asian J Trop Med Public Health
;
1996 Sep; 27(3): 530-4
Article
in English
| IMSEAR
| ID: sea-30878
ABSTRACT
Infection of mice with Plasmodium berghei engendered a temporary appearance of granulocyte-macrophage colony-stimulating factor (GM-CSF) in the serum. The peak of GM-CSF levels was detected at day 2 post-infection, and then gradually decreased. On the other hand, the number of committed stem cells for granulocytes and macrophages (CFU-GM) in bone marrow transiently decreased at day 2 post-infection, and then increased and peaked at day 6 post-infection. When the serum of P. berghei-infected mice was fractionated by gel chromatography on Sephacryl S-300, GM-CSF activity was detected as a single peak with an apparent molecular weight of 64 KDa. GM-CSF was entirely adsorbed to concanavalin A-Sepharose 4B affinity chromatography, and was sensitive to pronase digestion, indicating its glycoprotein nature. These results suggest that the circulating GM-CSF would contribute the increase of granulocyte-macrophage hemopoiesis in the early phase of malaria.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Plasmodium berghei
/
Time Factors
/
Granulocyte-Macrophage Colony-Stimulating Factor
/
Disease Models, Animal
/
Hematopoiesis
/
Animals
/
Malaria
/
Mice
/
Mice, Inbred Strains
Type of study:
Prognostic study
Language:
English
Journal:
Southeast Asian J Trop Med Public Health
Year:
1996
Type:
Article
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