Initial treatment of cryptococcal meningitis in AIDS.
Southeast Asian J Trop Med Public Health
;
2005 Jan; 36(1): 170-3
Article
in English
| IMSEAR
| ID: sea-30987
ABSTRACT
The comparison of initial treatment with amphotericin B (0.7 mg/kg/d) plus rifampin (600 mg/d) with amphotericin B (0.7 mg/kg/d) alone for 2 weeks, both followed by fluconazole (400 mg/ d) for 8 weeks in the acute treatment of cryptococcal meningitis in AIDS by an open- randomized, controlled, prospective clinical trial is reported. Twenty patients were enrolled in each group. There were no significant differences between the groups in regard to a negative CSF culture for Cryptococcus neoformans in the 2nd and 10th weeks of treatment, time until normal body temperature after treatment, number of patients who died, and persistence of high CSF pressure after completion of treatment. Elevated intracranial pressure was an important factor associated with the patients who died. These results indicate that the combination of amphotericin B plus rifampin is not superior to amphotericin B alone.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Rifampin
/
Female
/
Humans
/
Male
/
Fluconazole
/
Amphotericin B
/
Prospective Studies
/
Meningitis, Cryptococcal
/
AIDS-Related Opportunistic Infections
/
Adult
Type of study:
Controlled clinical trial
/
Observational study
Language:
English
Journal:
Southeast Asian J Trop Med Public Health
Year:
2005
Type:
Article
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