Indirect hemagglutination antibodies against Burkholderia pseudomallei in normal blood donors and suspected cases of melioidosis in Malaysia.
Southeast Asian J Trop Med Public Health
;
1996 Jun; 27(2): 263-6
Article
in English
| IMSEAR
| ID: sea-31081
ABSTRACT
Interpretation of the indirect hemagglutination test (IHA) for melioidosis in endemic areas is difficult because of the presence of antibodies in apparently healthy individuals. Fifty-three out of 200 healthy blood donors in Malaysia showed positive antibody titers (> or = 1 40) against Burkholderia pseudomallei. Seven percent had an IHA titer of 1 40, 11% had an IHA titer of 1 80 while 8.5% had a titer > or = 1 160. Out of 258 sera sent for melioidosis serology, 7% of the patients had an IHA titer of 1 40, 9% had an IHA titer of 1 80 while 20% had an IHA titer of > or = 1 160. If a titer of > or = 1 80 is taken as cut off point for positivity, 29% of the patients had positive melioidosis serology. Increasing the positivity threshold may jeopardize the sensitivity of the test. A more specific and sensitive test is needed.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Blood Donors
/
Humans
/
Hemagglutination Tests
/
Mass Screening
/
Prevalence
/
Reproducibility of Results
/
Sensitivity and Specificity
/
Burkholderia pseudomallei
/
Endemic Diseases
/
Malaysia
Type of study:
Diagnostic study
/
Prevalence study
/
Prognostic study
/
Screening study
Country/Region as subject:
Asia
Language:
English
Journal:
Southeast Asian J Trop Med Public Health
Year:
1996
Type:
Article
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