Lack of association between interleukin-10 gene promoter polymorphism, -1082G/A, and severe malaria in Thailand.
Southeast Asian J Trop Med Public Health
;
2002 ; 33 Suppl 3(): 5-7
Article
in English
| IMSEAR
| ID: sea-31238
ABSTRACT
Interleukin-10 (IL-10) is an important cytokine in the down-regulation of inflammatory responses, and it has been reported that a low plasma concentration of IL-10 is associated with severe anemia and cerebral malaria in Plasmodium falciparum infections. The IL-10 gene is located on chromosome 1q31-32, and a promoter polymorphism (-1082G/A) is known to affect IL-10 protein production. In order to examine the possible association of the -1082G/A polymorphism with the severity of malaria, we studied 203 mild malaria, 164 non-cerebral severe malaria, and 109 cerebral malaria patients living in northwest Thailand. The genotyping was performed by a fluorescence resonance energy transfer (FRET) method. The frequencies of a major allele -1082A in mild malaria, in non-cerebral severe malaria, and in cerebral malaria patients were 92.6%, 92.1%, and 92.7% respectively. Our results showed no significant association of the -1082G/A polymorphism with the severity of malaria.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Polymorphism, Genetic
/
Thailand
/
Severity of Illness Index
/
Humans
/
Base Sequence
/
Adolescent
/
Promoter Regions, Genetic
/
Malaria, Falciparum
/
Interleukin-10
/
DNA Primers
Country/Region as subject:
Asia
Language:
English
Journal:
Southeast Asian J Trop Med Public Health
Year:
2002
Type:
Article
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