Transient, acquired glucose-6-phosphate dehydrogenase deficiency in Thai children with typhoid fever.
Southeast Asian J Trop Med Public Health
;
1982 Mar; 13(1): 105-9
Article
in English
| IMSEAR
| ID: sea-31381
ABSTRACT
Seventy nine children with typhoid fever were studied, 45 were males and 34 were females. There were 9 out of 45 males patients (20%) who had definite G-6-PD deficiency of whom 3 had acute intravascular hemolysis. The rest of the patients had transient low enzyme activity during the first few weeks of their illness, with reticulocytopenia. Their G-6-PD activities rose up to normal level later in the course of the disease while the reticulocytes were also increased. This study demonstrated that even in normal G-6-PD subjects, typhoid fever can cause transient, acquired low G-6-PD level due to bone marrow suppression. It was suggested from this study that quantitative G-6-PD assay was more useful and sensitive than the screening method and that long term follow up is needed in the case that had unexplained low G-6-PD activity.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Thailand
/
Typhoid Fever
/
Female
/
Humans
/
Male
/
Child
/
Child, Preschool
/
Glucosephosphate Dehydrogenase
/
Glucosephosphate Dehydrogenase Deficiency
Country/Region as subject:
Asia
Language:
English
Journal:
Southeast Asian J Trop Med Public Health
Year:
1982
Type:
Article
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