Detection of circulating antigens and immune complexes in feline and human lymphatic filariasis.
Southeast Asian J Trop Med Public Health
;
1981 Dec; 12(4): 492-8
Article
in English
| IMSEAR
| ID: sea-31439
ABSTRACT
Circulating worm antigens were detected in 61% to 81% of sera from Brugia pahangi -infected cats and in 0-93% of sera from humans with malayan of bancroftian filariasis by counter immunoelectrophoresis and a double antibody sandwich enzyme-linked immunosorbent assay, using rabbit antisera to B. pahangi adult worms. In some situations, both antigen tests were as sensitive as antibody tests. However, ELISA was likely to be affected by the presence of antiglobulins, such as rheumatoid factor, in the test sera. Only 10% to 22% of B. pahangi-infected cats (treated with drugs or not) had circulating immune complexes by the conglutinin-binding assay and no sera were positive by C1q-BA. A significantly higher percentage (56%) of B. malayi clinical sera was positive for immune complexes by either C1q- or conglutinin- binding assays as compared to other groups of B. malayi and Wuchereria bancrofti sera (6% to 14%).
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Wuchereria bancrofti
/
Brugia
/
Humans
/
Counterimmunoelectrophoresis
/
Enzyme-Linked Immunosorbent Assay
/
Cats
/
Filariasis
/
Animals
/
Antigen-Antibody Complex
/
Antigens
Type of study:
Diagnostic study
Language:
English
Journal:
Southeast Asian J Trop Med Public Health
Year:
1981
Type:
Article
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