Mefloquine-pyrimethamine-sulfadoxine combination delays emergence of mefloquine resistant Plasmodium falciparum in continuous culture.
Southeast Asian J Trop Med Public Health
;
1984 Dec; 15(4): 531-5
Article
in English
| IMSEAR
| ID: sea-31884
ABSTRACT
The efficacy of mefloquine against Plasmodium falciparum in continuous culture was studied. The development of mefloquine resistance in P. falciparum was significantly inhibited by a combination of mefloquine, pyrimethamine and sulfadoxine. By contrast, more resistant variants were selected in continuous culture without drug pressure or with pyrimethamine-sulfadoxine pressure. The most mefloquine resistant variants were selected by step-wise increases in mefloquine pressure.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Plasmodium falciparum
/
Quinolines
/
Sulfadoxine
/
Sulfanilamides
/
Drug Resistance, Microbial
/
Mefloquine
/
Drug Combinations
/
Animals
/
Antimalarials
Language:
English
Journal:
Southeast Asian J Trop Med Public Health
Year:
1984
Type:
Article
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