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The efficacy of a single-oral-dose administration of ivermectin and diethylcarbamazine on the treatment of feline Brugia malayi.
Southeast Asian J Trop Med Public Health ; 2005 Sep; 36(5): 1105-9
Article in English | IMSEAR | ID: sea-31935
ABSTRACT
The combination of ivermectin and diethylcarbamazine (DEC) have been shown to be superior to either drug alone for the suppression of Brugia malayi in humans, but their efficacy against infection with B. malayi in cats has never been investigated. Fourteen asymptomatic microfilaremic (1-200 microfilariae/20 microl blood) cats received oral doses of ivermectin (400 microg/kg body weight) and DEC (6 mg/kg body weight) as a single treatment. A two-month post-treatment examination revealed that 87-100% of the microfilariae in each subject had been cleared, with two of the subjects being amicrofilaremic. A further reduction in microfilarial levels was observed until the final follow-up, at 8 months post-treatment, when the mean clearance rate was 99% and 12 out of the 14 subjects (86%) were amicrofilaremic. The combination of ivermectin and DEC demonstrated a microfilaricidal effect superior to that of either drug used alone, both in the initial rapid clearance of microfilariae, and in sustaining the effect for 8 months. This finding has important implications for the control of brugian lymphatic filariasis in the cat reservoir.
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Full text: Available Index: IMSEAR (South-East Asia) Main subject: Thailand / Ivermectin / Female / Male / Base Sequence / Cat Diseases / Cats / Treatment Outcome / Brugia malayi / DNA Primers Country/Region as subject: Asia Language: English Journal: Southeast Asian J Trop Med Public Health Year: 2005 Type: Article

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Full text: Available Index: IMSEAR (South-East Asia) Main subject: Thailand / Ivermectin / Female / Male / Base Sequence / Cat Diseases / Cats / Treatment Outcome / Brugia malayi / DNA Primers Country/Region as subject: Asia Language: English Journal: Southeast Asian J Trop Med Public Health Year: 2005 Type: Article