Contrast-induced nephropathy.
Indian Heart J
;
2008 Mar-Apr; 60(2): 133-8
Article
in English
| IMSEAR
| ID: sea-3195
ABSTRACT
Contrast-induced nephropathy (CIN) is a fairly common yet under-recognized clinical condition in the interventional cardiological practice. A 25% or more than 0.5 mg/dl rise of serum creatinine is generally accepted as defining CIN. The most important risk factors for CIN are pre-existing renal disease, volume of contrast media, nature of contrast media, and diabetes mellitus. Among the various postulated pathophysiological mechanisms for the precipitation of CIN, intra-renal vasoconstriction, and oxidative tubular injury are the best documented. Effective strategies to prevent CIN include adequate peri-procedural hydration with normal saline, use of N-acetylcysteine, keeping the volume of contrast media as low as feasible, and avoiding high-osmolal ionic contrast media. However, more efficient and cost-effective strategies are being developed and the search for the ideal contrast media is still on.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Vasoconstriction
/
Humans
/
Endothelium, Vascular
/
Risk Factors
/
Contrast Media
/
Creatine
/
Kidney Diseases
/
Nitric Oxide
Type of study:
Etiology study
/
Risk factors
Language:
English
Journal:
Indian heart j
Year:
2008
Type:
Article
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