Comparative study of LDL-cholesterol levels in Thai patients by the direct method and using the Friedewald formula.
Southeast Asian J Trop Med Public Health
;
2007 May; 38(3): 519-27
Article
in English
| IMSEAR
| ID: sea-32154
ABSTRACT
In this study, low-density lipoprotein cholesterol (LDL-C) levels by direct measurement and estimation using the Friedewald formula, were compared among 1,016 Thai patients. The study assessed blood samples from out-patients sent to the Clinical Chemistry Laboratory, Department of Clinical Pathology, Rajvithi Hospital, Ministry of Public Health, for measurement of total cholesterol (TC), LDL-C, high-density lipoprotein cholesterol (HDL-C) and triglyceride (TG) levels, January 2004-December 2005. Patients' ages ranged 8-89 years, 573 (56.4%) were females. Linear regression analysis showed the two methods had highly significant correlation coefficients (p<0.001). Upon comparing the two methods, at TG levels of 151-200 mg/dl, bias was 18.3 mg/dl; and for TG levels of 201-300 mg/dl, bias was lower at 11.4 mg/dl; for TG levels of 301-400 mg/dl, bias increased to 20.9 mg/dl. The direct assay meets currently established analytical performance targets and may be useful for the diagnosis and management of hyperlipidemic patients. The Friedewald formula did not give a homogeneous performance when estimating LDL-C levels in samples with different TG levels.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Thailand
/
Aged, 80 and over
/
Algorithms
/
Aged
/
Female
/
Humans
/
Male
/
Child
/
Adolescent
/
Adult
Limits:
Aged80
Country/Region as subject:
Asia
Language:
English
Journal:
Southeast Asian J Trop Med Public Health
Year:
2007
Type:
Article
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