K-ras oncogene and p53 gene mutations in cholangiocarcinoma from Thai patients.
Southeast Asian J Trop Med Public Health
;
1998 Mar; 29(1): 71-5
Article
in English
| IMSEAR
| ID: sea-32390
ABSTRACT
Paraffin embedded tissues from twenty Thai patients with intrahepatic cholangiocarcinomas were studied for K-ras gene mutations at codon 12, 13 and 61 and for p53 gene mutations in exon 5 to 8 using polymerase chain reaction and thermal cycle sequencing. Results showed that point mutations at these regions in K-ras oncogene were not present in all the samples. One case harbored a p53 gene mutation in codon 282 in exon 8, CGG (arginine) to TGG (tryptophan), but the mutation was not found in other patient's tissues with similar histological features.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Thailand
/
Bile Duct Neoplasms
/
Bile Ducts, Intrahepatic
/
Female
/
Humans
/
Male
/
Polymerase Chain Reaction
/
Genes, p53
/
Genes, ras
/
Cholangiocarcinoma
Country/Region as subject:
Asia
Language:
English
Journal:
Southeast Asian J Trop Med Public Health
Year:
1998
Type:
Article
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