Ovalocytosis in Papua New Guinea -- dominantly inherited resistance to malaria.
Southeast Asian J Trop Med Public Health
;
1981 Dec; 12(4): 549-55
Article
in English
| IMSEAR
| ID: sea-32473
ABSTRACT
Analysis of ovalocytosis in families has demonstrated dominant inheritance. This conclusion is based on finding ovalocytic children of ovalocytic Melanesian mothers and normocytic Caucasian fathers. Inheritance of resistance to thermal deformation and to crenation upon storage correlated with inheritance of ovalocytic erythrocyte morphology. The latter was associated with in vitro resistance to invasion by P. falciparum.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Papua New Guinea
/
Pedigree
/
Female
/
Humans
/
Male
/
Elliptocytosis, Hereditary
/
Erythrocytes
/
Genes, Dominant
/
Immunity, Innate
/
Malaria
Language:
English
Journal:
Southeast Asian J Trop Med Public Health
Year:
1981
Type:
Article
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