Risk of a couple having a child with severe thalassemia syndrome, prevalence in lower northern Thailand.
Southeast Asian J Trop Med Public Health
;
2006 Mar; 37(2): 366-9
Article
in English
| IMSEAR
| ID: sea-32541
ABSTRACT
Thalassemia screening in pregnant women and their spouses was performed at Buddhachinaraj Provincial Hospital and 8 community hospitals in Phitsanulok; lower northern Thailand. The prevalence of thalassemic carrier state was determined of 1,198 couples. Of these, 4.8% had heterozygous alpha thalassemia-1, 1.6% had heterozygous beta thalassemia, 12.4% had heterozygous hemoglobin (Hb) E, 2.7% had homozygous Hb E and 0.25% of others had abnormal Hb. Eighteen at risk couples (1.5%) were identified. Fifteen couples were at risk for compound heterozygous Hb E / beta thalassemia and the remaining 3 were at risk for homozygous alpha thalassemia-1. Prenatal diagnosis (cordocentesis) was performed in 4 couples at risk, but no fetuses with severe thalassemic disease were detected.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Pregnancy Complications, Hematologic
/
Prenatal Diagnosis
/
Syndrome
/
Thailand
/
Thalassemia
/
Female
/
Humans
/
Male
/
Pregnancy
/
Carrier State
Type of study:
Diagnostic study
/
Etiology study
/
Prevalence study
/
Prognostic study
/
Risk factors
/
Screening study
Country/Region as subject:
Asia
Language:
English
Journal:
Southeast Asian J Trop Med Public Health
Year:
2006
Type:
Article
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