The value of potency testing of poliomyelitis and measles vaccines as an integral part of cold chain surveillance.
Southeast Asian J Trop Med Public Health
;
1993 Jun; 24(2): 265-8
Article
in English
| IMSEAR
| ID: sea-32894
ABSTRACT
The Virology Division in the Institute for Medical Research, Kuala Lumpur, Malaysia performs potency tests on oral polio vaccines and live attenuated measles vaccines. Since these potency tests were introduced in 1981 a total of 752 tests have been performed on vaccine samples from peripheral immunization centers. Of 165 representative vaccine samples sent for potency evaluation after a cold chain breakdown 154 (87%) passed minimum potency requirements recommended for immunization of infants. In the absence of potency evaluation, those vaccines exposed to temperatures higher than the recommended storage range would be discarded, perhaps resulting in unnecessary wastage and economic loss. Results of the vaccine potency evaluation has enabled health authorities to indirectly monitor cold chain efficiency and ensure the high quality of viral vaccines used in our childhood immunization program.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Humans
/
Measles Vaccine
/
Poliovirus Vaccine, Oral
/
Cell Line
/
Titrimetry
/
Cytopathogenic Effect, Viral
/
Animals
/
Macaca fascicularis
Type of study:
Screening study
Language:
English
Journal:
Southeast Asian J Trop Med Public Health
Year:
1993
Type:
Article
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