Genetic control of immune responses to Schistosoma japonicum.
Southeast Asian J Trop Med Public Health
;
1984 Dec; 15(4): 518-22
Article
in English
| IMSEAR
| ID: sea-32918
ABSTRACT
The mouse IgE antibody response to S. japonicum antigen (Sj) was found to be under control of a gene(s) linked to the major histocompatibility complex. In some strains but not all among low responders, however, T cell responsiveness to Sj could be demonstrated by the induction of carrier effect as well as by proliferation response. Resistance to reinfection with a large dose of S. japonicum cercariae was demonstrated in most strains examined, except C57BL/6, irrespective of the immune responsiveness. Further studies will be needed to elucidate whether genetically regulated immune responses may affect susceptibility to or pathogenesis of schistosomiasis japonica in the mouse.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Schistosoma japonicum
/
Schistosomiasis
/
Immunoglobulin E
/
H-2 Antigens
/
Genes, MHC Class II
/
Animals
/
Mice
/
Mice, Inbred Strains
/
Antibodies
Language:
English
Journal:
Southeast Asian J Trop Med Public Health
Year:
1984
Type:
Article
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