Etiology and outcome of superior vena cava (SVC) obstruction in adults.
Southeast Asian J Trop Med Public Health
;
2004 Jun; 35(2): 453-7
Article
in English
| IMSEAR
| ID: sea-32993
ABSTRACT
Between 1997 and 2002, 107 patients with symptoms of superior vena cava (SVC) obstruction presented at a university hospital in Northeast Thailand. Age averaged 50.7 years (range, 1 to 84). The male to female ratio was 5.71. Duration of symptoms before diagnosis was 29.4 days (range, 2 to 240), including facial swelling, cough, and chest discomfort. About 20% of cases developed respiratory failure and 11.2% died shortly after admission. The mean hospital stay was 23.7 days. Anteroposterior and lateral chest radiographs and computed chest tomography helped locate the lesion. Transbronchial biopsy through bronchoscopy, transthoracic needle biopsy under computed tomography, lymph node biopsy, pleural fluid cytology and/or biopsy were used for histopathologic sampling. High levels of alpha-fetoprotein and beta-HCG indicated an anterior mediastinal mass. The most common etiology of SVC obstruction was bronchogenic carcinoma (51.8%), followed by an anterior mediastinal mass (14.5%), lymphoma (13.6%--with an LDH of 262 to 1459 U/l), metastatic cancer (9.1%), and acute lymphoblastic leukemia (1.8%). Benign SVC thrombosis was found in four patients with Behcet's disease or some other idiopathy. Mediastinal fibrosis from melioidosis occurred in three patients, which is rare, has not been previouly reported. Most patients (63.6%) received a combination of radiotherapy and corticosteroid and this helped 55.2% improve.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Thailand
/
Vena Cava, Superior
/
Aged, 80 and over
/
Superior Vena Cava Syndrome
/
Aged
/
Female
/
Humans
/
Male
/
Carcinoma, Bronchogenic
/
Cross-Sectional Studies
Type of study:
Etiology study
/
Observational study
/
Prevalence study
/
Risk factors
Limits:
Aged80
Country/Region as subject:
Asia
Language:
English
Journal:
Southeast Asian J Trop Med Public Health
Year:
2004
Type:
Article
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