A sensitive assay for anti-HIV-1 drug discovery in a biological safety level-2 laboratory.
Southeast Asian J Trop Med Public Health
;
1998 Dec; 29(4): 758-62
Article
in English
| IMSEAR
| ID: sea-33137
ABSTRACT
Studies involving infectious, wild type HIV-1 must be performed under strict BSL-3 practice. We have employed a defective (deltaTat/Rev)MC99 and cloned 1A2 line, ie, mutated HIV-1 and Tat/Rev transfected cells to verify anti-HIV-1 activity in a BSL-2 laboratory. A number of extracts from various parts of 11 species of plants were studied. Results were correlated with those of an anti-HIV-1 reverse transcriptase (RT) assay.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Biological Assay
/
Humans
/
Plant Extracts
/
Drug Design
/
Giant Cells
/
Reverse Transcriptase Inhibitors
/
Anti-HIV Agents
/
Cytoprotection
/
HIV Reverse Transcriptase
/
Laboratory Infection
Language:
English
Journal:
Southeast Asian J Trop Med Public Health
Year:
1998
Type:
Article
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