In vivo efficacy of levamisole against larval stages of Angiostrongylus cantonensis and A. costaricensis.
Southeast Asian J Trop Med Public Health
;
1989 Mar; 20(1): 109-17
Article
in English
| IMSEAR
| ID: sea-33211
ABSTRACT
Anti-larval effects of levamisole were examined on A. cantonensis in rats and A. costaricensis in mice. 1) In rats inoculated with 40 infective larvae of A. cantonensis Compared with a non-treated control group, a significant reduction in number of worms recovered was seen in the group receiving a single dose of 1.0 mg/kg or more. A significant decrease in host lung-body weight ratio was seen in the group receiving drug of 3.0 mg/kg or more. 2) In mice inoculated with 20 infective larvae of A. costaricensis. In the non-treated control group, a severe loss in body weight and death of host animals were observed. A single dose of 30 mg/kg on 3, 4 or 5 days post-infection remarkably inhibited these changes. At 30 mg/kg for 3 or 7 days levamisole was more effective than a single dose of the drug. These results suggest that levamisole has conspicuous in vivo effects against larval stages of A. costaricensis as well as A. cantonensis.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Rats
/
Rats, Inbred Strains
/
Body Weight
/
Male
/
Levamisole
/
Administration, Oral
/
Drug Evaluation, Preclinical
/
Angiostrongylus
/
Animals
/
Mice
Language:
English
Journal:
Southeast Asian J Trop Med Public Health
Year:
1989
Type:
Article
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