Mutations at the activated protein C cleavage sites Arg336 and Arg562 of factor VIII in Thai patients with venous thrombosis.
Southeast Asian J Trop Med Public Health
;
2001 Dec; 32(4): 880-3
Article
in English
| IMSEAR
| ID: sea-33618
ABSTRACT
Venous thrombosis is a multicausal disease, more than one genetic risk factor may cooperate to effect thrombotic risk. Factor V Leiden is found to be an important hereditary risk factor for venous thromboembolism. Analogous to factor V Leiden, a point mutation at amino acid positions Arg336 and Arg562 in factor VIII may predispose patients to thrombosis. Eighty-one Thai patients with venous thrombosis and 100 Thai healthy volunteers have been studied. Neither heterozygous nor homozygous mutations were detected both thrombosis patients or normal volunteers. However, further studies with larger samples of venous thrombosis patients are recommended.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Arginine
/
Thailand
/
Aged
/
Female
/
Humans
/
Male
/
Factor VIII
/
Protein C
/
Base Sequence
/
Case-Control Studies
Type of study:
Observational study
/
Risk factors
Country/Region as subject:
Asia
Language:
English
Journal:
Southeast Asian J Trop Med Public Health
Year:
2001
Type:
Article
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