Can treatment of P. vivax lead to a unexpected appearance of falciparum malaria?
Article
in English
| IMSEAR
| ID: sea-33632
ABSTRACT
Of 994 patients admitted to the Bangkok Hospital for Tropical Diseases for P. vivax malaria, 104 (10.5%) experienced appearance of Plasmodiumfalciparum following drug treatment for P. vivax . In all patients, P. falciparum parasites were not found by microscopic examination upon admission. The mean time for P. falciparum appearance was 12.6 days after the commencement of chloroquine treatment. Patients experiencing appearance of P. falciparum had significantly lower hematocrit, and greater initial P. vivax parasite counts. We use a mathematical model to explore the consequences of chloroquine treatment of such mixed infections. Both clinical results and features of the model suggest that such "hidden infections" may be quite common, and that the appearance of P. falciparum may be stimulated by treatment of P. vivax.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Plasmodium falciparum
/
Plasmodium vivax
/
Thailand
/
Humans
/
Male
/
Chloroquine
/
Malaria, Vivax
/
Malaria, Falciparum
/
Adult
/
Animals
Country/Region as subject:
Asia
Language:
English
Year:
2001
Type:
Article
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