Malaria species and Southeast Asian ovalocytosis defined by a 27-bp deletion in the erythrocyte band 3 gene.
Southeast Asian J Trop Med Public Health
;
2002 Mar; 33(1): 4-6
Article
in English
| IMSEAR
| ID: sea-33799
ABSTRACT
To evaluate the resistance of SAO against species specific malaria infection, relationships between parasite species and the 27-bp deletion in the band 3 gene were studied in malaria endemic Sumba Island, eastern Indonesia. Thick blood films were prepared from patients with malaria symptoms (n=129) and healthy controls (n=231). Species of Plasmodium was identified by microscopic observation. The 27-bp deletion was screened by the PCR method. Among 231 healthy controls, 29 (12.6%) had the 27-bp deletion, whereas 14 (10.9%) among 129 patients confirmed with malaria infection harbored the 27-bp deletion. No significant difference was observed in the prevalence of the 27-bp deletion between controls and patients (p>0.8). There was no significant difference in the frequency of the 27-bp deletion between P. vivax and P. falciparum infected subjects at 5% level by Fisher's exact test. The present result showing no correlation between the presence of the 27-bp deletion and infected parasite species is consistent with the post-invasion resistance hypothesis that may involve not a single malaria species.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Plasmodium
/
Asia, Southeastern
/
Humans
/
Anion Exchange Protein 1, Erythrocyte
/
Case-Control Studies
/
Sequence Deletion
/
Elliptocytosis, Hereditary
/
Indonesia
/
Animals
/
Malaria
Type of study:
Observational study
/
Risk factors
Country/Region as subject:
Asia
Language:
English
Journal:
Southeast Asian J Trop Med Public Health
Year:
2002
Type:
Article
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