Antibacterial activity of teicoplanin against Clostridium difficile.
Southeast Asian J Trop Med Public Health
;
1996 Sep; 27(3): 606-9
Article
in English
| IMSEAR
| ID: sea-33933
ABSTRACT
The in vitro inhibitory action of teicoplanin, vancomycin, metronidazole and clindamycin against clinical isolates of Clostridium difficile was investigated. Minimum inhibitory concentrations (MICs) were determined using E test. Teicoplanin (MIC range 0.023-0.75 microgram/ml), vancomycin (MIC range 0.5-3 micrograms/ml) and metronidazole (MIC range 0.19-1 microgram/ml) were all very active against the isolates examined. No resistant strains of C. difficile to those three antimicrobial agents were observed, whereas resistance to clindamycin was found in 39.5% of the tested strains. Teicoplanin was about 4-times more potent than vancomycin. It appears to be a more promising antimicrobial for treatment of C. difficile enteric disease.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Clindamycin
/
Vancomycin
/
Microbial Sensitivity Tests
/
Clostridioides difficile
/
Teicoplanin
/
Dose-Response Relationship, Drug
/
Metronidazole
/
Anti-Bacterial Agents
/
Antitrichomonal Agents
Language:
English
Journal:
Southeast Asian J Trop Med Public Health
Year:
1996
Type:
Article
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