The significance of HER-2/neu/c-erbB-2 gene amplification in benign and malignant breast disease.
Southeast Asian J Trop Med Public Health
;
1997 Sep; 28(3): 631-40
Article
in English
| IMSEAR
| ID: sea-33957
ABSTRACT
This study was carried out to investigate the amplification of HER-2/neu oncogene in 66 patients with primary breast cancer and 90 samples from benign breast disease (BBD). The amplification of HER-2/neu oncogene in the DNA of paraffin-embedded specimens was determined by differential PCR. Nineteen out of 66 (28.8%) breast cancer patients showed amplification of the gene. No gene amplification was found in benign breast disease. There was no significant correlation of HER-2/neu amplification with, age, menopausal status, the number of positive nodes, tumor size, estrogen receptor, however, amplification of HER-2/neu gene was strongly correlated with nodal status (p = 0.0049). In node positive patients, the incidence of HER-2/neu amplification was high (43%). These findings indicate that the amplification of HER-2/neu gene may be of pathogenetic significance in breast cancer and may have a poor prognosis in node positive breast cancer patients while no gene amplification in benign breast disease suggests that HER-2/neu amplification is a late molecular alteration event in the pathogenesis of breast cancer.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Prognosis
/
Breast Diseases
/
Breast Neoplasms
/
Aged
/
Female
/
Humans
/
Menopause
/
Gene Amplification
/
Polymerase Chain Reaction
/
Incidence
Type of study:
Diagnostic study
/
Etiology study
/
Incidence study
/
Prognostic study
/
Risk factors
Language:
English
Journal:
Southeast Asian J Trop Med Public Health
Year:
1997
Type:
Article
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